Autoimmune Responses in the Rheumatoid Synovium
نویسندگان
چکیده
منابع مشابه
Autoimmune Responses in the Rheumatoid Synovium
Perspective R heumatoid arthritis (RA) is a chronic inflammatory disorder affecting joints, often with severe and disabling consequences. Although cells and intracellular signals characterizing inflamed tissue in RA are not qualitatively different from those found in other conditions, in about one third of patients with RA ectopic lymphoid structures can be found in affected tissue [1]. These s...
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Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The synovium is the primary site of the inflammatory process, which if untreated leads to irreversible damage to the adjacent cartilage and bone. It is now well established that autoantibodies that are characteristic of RA, including rheumatoid factor (RF) and anti-citrulluninated protein antibodies (ACPA), are...
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A gene therapy of synovial tissue is potentially a novel therapeutic method in rheumatoid arthritis (RA). The method induces expression of anti-arthritic molecules in target cells, and is also useful for the investigation of novel therapeutic targets in vitro. Previous studies showed that viral vectors, which can infect non-proliferative cells well, i.e. adenovirus-based vector, were effective ...
متن کاملCorrection: Cells of the synovium in rheumatoid arthritis. Chondrocytes
After publication of our recent article [1], we noticed an error in the third sentence of the third paragraph of the section entitled, 'Joint inflammation and cartilage remodeling in RA'. This sentence should read: ADAMTS-5 is expressed constitutively, whereas ADAMTS-4 is more prominently regulated by inflammatory cytokines.
متن کاملCells of the synovium in rheumatoid arthritis. Dendritic cells
Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-kappaB and the secretion of TNF and IL-1 drive the maturation of dendritic ...
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ژورنال
عنوان ژورنال: PLoS Medicine
سال: 2009
ISSN: 1549-1676
DOI: 10.1371/journal.pmed.1000009